関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 8-Quinolinecarboxylic acid | HCID 66582 | — |
| 反応物 | 1-methyl-1H-tetrazol-5-amine | HCID 138492 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 8-(1-methyl-1H-tetrazole-5-ylcarbamoyl)quinoline | HCID 13192304 | — |
反応手順
A mixture of 2.4 g. (0.020 mole) of 8-quinolinecarboxylic acid and 3.0 g. (0.030 mole) of 5-amino-1-methyltetrazole is stirred in 30 ml. of pyridine at 20° C. while adding 2.0 ml. of thionyl chloride dropwise. The mixture is heated at 70° C. for one hour. The reaction mixture is evaporated to provide a residue which is diluted with water. The solid is separated by filtration and recrystallized from acetic acid with decolorizing charcoal. The product is recrystallized a second time from acetic acid to provide 8-(1-methyl-1H-tetrazole-5-yl-carbamoyl)quinoline, m.p. 224°-225° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04147694 |
|---|
| 出典データセット | uspto-grants-1979_04 |
|---|
| ORD ID | ord-5f8e2eace96a4a629a7b0b416dcdcf5b |
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| 出典メモ | uspto-grants-1979_04 |
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