Methyl vinyl ketone → HCID 14663656、化合物

反応式

[CH:1](=[O:8])[CH2:2][CH2:3][C:4]#[C:5][CH2:6][CH3:7].[CH:9]([C:11]([CH3:13])=[O:12])=[CH2:10].C(N(CC)CC)C>>[CH3:13][C:11](=[O:12])[CH2:9][CH2:10][C:1](=[O:8])[CH2:2][CH2:3][C:4]#[C:5][CH2:6][CH3:7]

参加物

反応物 3

HCID 6570Methyl vinyl ketone

HCID 8471Triethylamine

HCID 18330928Hept-4-ynal

生成物 1

HCID 14663656HCID 14663656、化合物

実験手順

22.0 g (0.2 mol) of hept-4-in-1-al, 14 g (0.2 mol) of methyl vinyl ketone, 5.4 g (0.02 mol) of Cat. 1 and 12.6 g (0.12 mol) of triethylamine are brought together in the manner described in Example 26. After 12 hours' reaction time at a surrounding temperature of 80° C in a nitrogen atmosphere, the mixture is worked up in the manner described in Example 21. On subsequent fractionation, undec-8-ine-2,5-dione is obtained.