関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoro-N-methylaniline | HCID 68024 | — |
| 反応物 | 3,5-Dibromopyridine | HCID 69369 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-bromo-N-(4-fluorophenyl)-N-methylpyridin-3-amine | HCID 104531697 | 0% |
反応手順
In a 50 mL round-bottomed flask (t=g) was 4-fluoro-N-methylaniline (.05 g, 0.40 mmol), 3,5-dibromopyridine (0.114 g, 0.48 mmol), and Pd2(dba)3 (0.018 g, 0.02 mmol) in toluene (16 mL) ([VOLUME]) to give a purple suspension. biphenyl-2-yldicyclohexylphosphine (0.021 g, 0.06 mmol) and CS2CO3 (0.195 g, 0.60 mmol) were added. After LC/MS indicated no reaction had taken place at room temp, the temperature was gradually rasied to up to 110 degrees. LC/MS indicated that the reaction was not progressing. Reaction was discarded.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-d1bfb220e27441fcb5908d58a9e8690c |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
