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Hydrochloric Acid → 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl cyanoacetate | HCID 7764 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-Hydroxy-7-methoxy-5-benzofurancarboxaldehyde | HCID 21785684 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid | HCID 21785685 | — |
反応手順
The aldehyde of Example 5 (192 mg., 1 mmole) in 1 ml. of water was added to a solution of ethyl cyanoacetate (125 mg., 1.1 mmole) in 1 ml. of water containing 200 mg. of sodium hydroxide. The mixture was stirred at room temperature for 20 hours then treated with 8 ml. of 2N HCl under reflux for 30 minutes. After cooling, the product was isolated by centrifugation followed by crystallization from ethanol to yield a yellow solid, m.p. 227°-228°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04147703 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-172d9fc38690431cb00e89f3fd122624 |
| 出典メモ | uspto-grants-1979_04 |