Ethanol → Ethyl 4-decylpiperazine-1-carboxylate

HRID 259066ノート

反応式

HRID 259066 の反応式
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])(=O)=O.[CH2:16]([O:18][C:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:20])[CH3:17].C(O)C.C(=O)([O-])[O-].[K+].[K+]>O.C(OCC)C>[CH2:16]([O:18][C:19]([N:21]1[CH2:22][CH2:23][N:24]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:25][CH2:26]1)=[O:20])[CH3:17]

参加物

7

反応物 4

HCID 702EthanolHCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 11430Potassium CarbonateHCID 5235508Decyl methanesulfonate

生成物 1

HCID 228932Ethyl 4-decylpiperazine-1-carboxylate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

77.3 Grams of decyl methylsulfonate, 44.64 grams of 1-ethoxycarbonylpiperazine, 500 ml. of ethanol, and 39 grams of potassium carbonate are combined and refluxed for approximately 44 hours under a nitrogen atmosphere. After cooling to room temperature the residue is dissolved in a mixture of water and ethyl ether. The organic layer is separated, washed three times with portions of water and dried over anhydrous sodium sulfate. The solvents are removed under reduced pressure to give 1-ethoxycarbonyl-4-decylpiperazine.

後処理

  1. temperaturerefluxed for approximately 44 hours under a nitrogen atmosphere
  2. customThe organic layer is separated
  3. washwashed three times with portions of water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvents are removed under reduced pressure

出典と根拠

ORDレコード
ord-2ab7a268626c4c259e68ae53ac0c746c
出典データセット
uspto-grants-1977_07
特許番号
US04036828

反応ノート

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