Aniline → 2,3-Dibromo-N-(phenylcarbamoyl)propanamide

HRID 259163ノート

反応式

HRID 259163 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:8][CH:9]([CH2:15][Br:16])[C:10]([N:12]=[C:13]=[O:14])=[O:11]>C1C=CC=CC=1>[C:2]1([NH:1][C:13]([NH:12][C:10](=[O:11])[CH:9]([Br:8])[CH2:15][Br:16])=[O:14])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 203185382,3-Dibromopropanoyl isocyanate

生成物 1

HCID 203185402,3-Dibromo-N-(phenylcarbamoyl)propanamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
12.5 °C

実験手順

9.5 g of aniline are dissolved in 100 ml of anhydrous benzene and a solution of 26.0 g of 2,3-dibromopropionyl isocyanate in 100 ml of benzene is added dropwise with cooling at 10 to 15° C. After stirring for 2 hours, the crystal sludge is diluted with the same volume of petroleum ether, filtered, washed with petroleum ether and dried. Yield: 30.0 g, m.p: 160°-161° C.

後処理

  1. filtrationfiltered
  2. washwashed with petroleum ether
  3. customdried

出典と根拠

ORDレコード
ord-280ea10ba53740659e5917008497853f
出典データセット
uspto-grants-1977_07
特許番号
US04036850

反応ノート

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