1-(2-Chloroethyl)piperidine → 2-(2-(1-Piperidinyl)ethylthio)-N,N'-p-phenylenebismethanesulfonamide Hydrochloride

HRID 25922

反応式

HRID 25922 の反応式
[SH:1][C:2]1[CH:7]=[C:6]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[NH:13][S:14]([CH3:17])(=[O:16])=[O:15].[N:18]1([CH2:24][CH2:25][Cl:26])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C(O)C>[ClH:26].[N:18]1([CH2:24][CH2:25][S:1][C:2]2[CH:7]=[C:6]([NH:8][S:9]([CH3:12])(=[O:10])=[O:11])[CH:5]=[CH:4][C:3]=2[NH:13][S:14]([CH3:17])(=[O:16])=[O:15])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

4

反応物 2

HCID 748271-(2-Chloroethyl)piperidineHCID 706057042-mercapto-N,N'-p-phenylenebismethanesulfonamide

生成物 1

HCID 706058602-(2-(1-Piperidinyl)ethylthio)-N,N'-p-phenylenebismethanesulfonamide Hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution containing 8.9 g (0.030 mole) of 2-mercapto-N,N'-p-phenylenebismethanesulfonamide dissolved in 500 ml of ethanol at 60° C. was added 4.7 g (0.032 mole) of 2-(1-piperidinyl)ethyl chloride with stirring. The reaction flask was then removed from the heat, and the mixture was allowed to cool to room temperature. At the end of a period of 15 hours the precipitated white solid product (8.9 g) was collected on a filter and dried. Recrystallization from a mixture of nitromethane and dimethylformamide gave the title compound as white crystals, m.p. 218°-218.5° C. dec.

後処理

  1. customThe reaction flask was then removed from the heat
  2. customAt the end of a period of 15 hours the precipitated white solid product (8.9 g) was collected on
  3. filtrationa filter
  4. customdried
  5. customRecrystallization
  6. additionfrom a mixture of nitromethane and dimethylformamide

出典と根拠

ORDレコード
ord-16bc665813b143e29c93a98dc8764fd4
出典データセット
uspto-grants-1979_04
特許番号
US04147723

関連ノート

読み込み中…