Dimethylamine → 1-(Dimethylamino)-1-octen-3-one
反応式
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]参加物
3
実験手順
A solution of dimethylamine (560 ml, 40% aqueous) is cooled to 5° C. 1-Chloro-1-octen-3-one (192 g) is added and the mixture stirred at room temperature for 20 min. The solution is then saturated with potassium carbonate and extracted with ether. The organic layer is washed 3 × with sat. sodium chloride solution, dried over sodium sulfate, concentrated and distilled to give the title compound, b.p. 94°-96° C./0.2mm.
後処理
- extractionsaturated with potassium carbonate and extracted with ether
- washThe organic layer is washed 3 × with sat. sodium chloride solution
- dry with materialdried over sodium sulfate
- concentrationconcentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-da35dbdcd7f34d7eb2f0ca7e02ca73e6
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04036856
反応ノート
読み込み中…