Dimethylamine → 1-(Dimethylamino)-1-octen-3-one

HRID 259229

反応式

HRID 259229 の反応式
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

3

反応物 2

HCID 674DimethylamineHCID 545149151-Chloro-1-octen-3-one

生成物 1

HCID 545630821-(Dimethylamino)-1-octen-3-one

実験手順

A solution of dimethylamine (560 ml, 40% aqueous) is cooled to 5° C. 1-Chloro-1-octen-3-one (192 g) is added and the mixture stirred at room temperature for 20 min. The solution is then saturated with potassium carbonate and extracted with ether. The organic layer is washed 3 × with sat. sodium chloride solution, dried over sodium sulfate, concentrated and distilled to give the title compound, b.p. 94°-96° C./0.2mm.

後処理

  1. extractionsaturated with potassium carbonate and extracted with ether
  2. washThe organic layer is washed 3 × with sat. sodium chloride solution
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. distillationdistilled

出典と根拠

ORDレコード
ord-da35dbdcd7f34d7eb2f0ca7e02ca73e6
出典データセット
uspto-grants-1977_07
特許番号
US04036856

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