Hydrochloric Acid → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride

HRID 259326ノート

反応式

HRID 259326 の反応式
[C:1]([C:4]1[S:8][C:7]2[CH2:9][CH2:10][CH2:11][CH:12]([NH:13]C(=O)C)[C:6]=2[CH:5]=1)(=[O:3])[CH3:2].[ClH:17]>O>[ClH:17].[C:1]([C:4]1[S:8][C:7]2[CH2:9][CH2:10][CH2:11][CH:12]([NH2:13])[C:6]=2[CH:5]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 20348948N-(2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-yl)acetamide

生成物 1

HCID 203489702-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The product from Example 23 (7.25 grams) is heated with 90 ml. of 1N hydrochloric acid at reflux temperature for 8.5 hours and cooled. The mixture is diluted with water and extracted with methylene chloride. The aqueous layer is then evaporated to dryness using 2-propanol for facilitating removal of water. This gives 4.85 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride.

後処理

  1. temperaturecooled
  2. extractionextracted with methylene chloride
  3. customThe aqueous layer is then evaporated to dryness
  4. customremoval of water

出典と根拠

ORDレコード
ord-9092cdb48ca747d4a844a200827c5533
出典データセット
uspto-grants-1977_07
特許番号
US04036979

反応ノート

読み込み中…