1-Aminohydantoin → alpha-[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]benzeneacetic acid, ethyl ester

HRID 259390

反応式

HRID 259390 の反応式
[NH2:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[N:9]([CH:12]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:10]=[O:11]>O1CCOCC1>[O:8]=[C:3]1[NH:4][C:5](=[O:7])[CH2:6][N:2]1[NH:1][C:10]([NH:9][CH:12]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:11]

参加物

4

反応物 2

HCID 728231-AminohydantoinHCID 56982438alpha-Isocyanatobenzeneacetic acid, ethyl ester

生成物 1

HCID 86734963alpha-[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]benzeneacetic acid, ethyl ester

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

1.15 g. (0.01 mol.) of 1-amino-2,4-dioxoimidazolidine are dissolved in 50 ml. of dioxane while heating. The solution is permitted to cool to room temperature while stirring, wherein a portion of the 1-amino-2,4-dioxoimidazolidine crystallizes out. 2.05 g. (0.01 mol.) of α-isocyanatobenzeneacetic acid, ethyl ester are added and the reation mixture is stirred overnight at room temperature. On the next day the mixture is concentrated and the residue is triturated with ether. 3.0 g. of α-[[[(2,4-dioxo-1-imidazolidinyl)amino]-carbonyl] amino]benzeneacetic acid, ethyl ester are obtained, m.p. 148°-151°.

後処理

  1. customwherein a portion of the 1-amino-2,4-dioxoimidazolidine crystallizes out
  2. stirringthe reation mixture is stirred overnight at room temperature
  3. concentrationOn the next day the mixture is concentrated
  4. customthe residue is triturated with ether

出典と根拠

ORDレコード
ord-5135711ffbba467f97cb00c6db5a74f4
出典データセット
uspto-grants-1977_07
特許番号
US04038271

関連ノート

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