Potassium Hydroxide → 4-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

HRID 259408ノート

反応式

HRID 259408 の反応式
Cl.[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([O:13]CC)=[O:12])[CH3:3].[OH-].[K+]>C(O)C>[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])[CH3:3]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 92019408HCID 92019408、化合物

生成物 1

HCID 214217464-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

28.5 g. of 4-ethoxy-2 -methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester, hydrochloride from Example 2 and 15 g. of potassium hydroxide are refluxed in 100 ml. of ethanol for 10 hours. The solvent is then distilled off and the residue is dissolved in 20 ml. of water. Acetic acid is added and a precipitate of 16 g. of 4-ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid; m.p. 222°-225° (DMF); is obtained.

後処理

  1. distillationThe solvent is then distilled off
  2. dissolutionthe residue is dissolved in 20 ml
  3. additionAcetic acid is added
  4. customis obtained

出典と根拠

ORDレコード
ord-6a3dd96a877940e3b5f88e5709f88c0d
出典データセット
uspto-grants-1977_07
特許番号
US04038283

反応ノート

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