Benzene → 2,5-Diphenyloxazolo[5,4-b]pyridine

HRID 259555

反応式

HRID 259555 の反応式
N[C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1.[N+]([O-])(OCCC(C)C)=O.[CH:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:11]1([C:9]2[O:8][C:6]3[C:5]([N:10]=2)=[CH:4][CH:3]=[C:2]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:7]=3)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 3

HCID 241BenzeneHCID 10985Isoamyl nitrateHCID 227547935-Amino-2-phenyloxazolo[5,4-b]pyridine

生成物 1

HCID 156656752,5-Diphenyloxazolo[5,4-b]pyridine

実験手順

A mixture of 180 mg. of 5-amino-2-phenyloxazolo[ 5,4-b]pyridine, 10 ml. of benzene and 0.2 ml. of isoamyl nitrate was refluxed for 11/2 hours. The hot solution was filtered and concentrated to dryness. The residue was extracted with ether and the extract was filtered through aluminum oxide and concentrated to dryness. The crystalline residue was recrystallized from ethyl acetate to give 2,5-diphenyloxazolo[ 5,4-b]pyridine, m.p. 151°-152° C.

後処理

  1. additionA mixture of 180 mg
  2. filtrationThe hot solution was filtered
  3. concentrationconcentrated to dryness
  4. extractionThe residue was extracted with ether
  5. filtrationthe extract was filtered through aluminum oxide
  6. concentrationconcentrated to dryness
  7. customThe crystalline residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-b544000962be4351a3834cd683a82c26
出典データセット
uspto-grants-1977_07
特許番号
US04038396

関連ノート

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