Benzyl Chloride → Benzylsuccinamate

HRID 259632

反応式

HRID 259632 の反応式
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([NH2:6])=[O:5].[CH2:9](Cl)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>CN(C)C=O>[C:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:7])[CH2:2][CH2:3][C:4]([NH2:6])=[O:5]

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 8471TriethylamineHCID 12522Succinamic acid

生成物 1

HCID 21470073Benzylsuccinamate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 23.4 g. (0.20 mole) of succinamic acid, 25.4 g. (0.20 mole) of benzyl chloride, 20.2 g. (0.20 mole) triethylamine and 250 ml. dimethylformamide is stirred at 95° C. for 20 hours. The reaction mixture is diluted with 500 ml. water the product extracted into two 200 ml. portions of ethyl ether. The combined ether extracts are washed with two 50 ml. portions of saturated sodium bicarbonate solution, then two 50 ml. portions of water and dried over anhydrous magnesium sulfate. After filtering, the solution is concentrated at 15 - 20 mm. and 40° C. to give benzyl succinamate.

後処理

  1. additionA mixture of 23.4 g
  2. additionThe reaction mixture is diluted with 500 ml
  3. extractionwater the product extracted into two 200 ml
  4. washThe combined ether extracts are washed with two 50 ml
  5. dry with materialportions of water and dried over anhydrous magnesium sulfate
  6. filtrationAfter filtering
  7. concentrationthe solution is concentrated at 15 - 20 mm

出典と根拠

ORDレコード
ord-dbaf64c2be9d4cd6abe44c88fc0774b9
出典データセット
uspto-grants-1977_07
特許番号
US04038411

関連ノート

読み込み中…