化工社化工社 化学情報印刷レポート · 研究参考用
4-Chlorophenol → 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenol | HCID 4684 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 1-Bromo-3,3-dimethyl-1-phenylbutan-2-one | HCID 13458693 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one | HCID 21326028 | 67% |
反応手順
A solution of 25.4 g (0.1 mole) of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one in 50 ml of ethyl acetate was added dropwise, at the boil, to a solution of 12.85 g (0.1 mole) of 4-chlorophenol and 2.3 g (0.1 mole) of sodium in 100 ml of ethanol. After boiling for 12 hours under reflux, the sodium bromide which had separated out was filtered off hot. The filtrate was distilled in vacuo and the solid residue which remained was recrystallized from ligroin. 20.2 g (67% of theory) of 1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one of melting point 103° C. were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04147791 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-2a6191e666fa47fc92c5b3dc0bd416f8 |
| 出典メモ | uspto-grants-1979_04 |