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Water → p-(4-Phenoxybutoxy) acetophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4'-Hydroxyacetophenone | HCID 7469 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (4-Bromobutoxy)benzene | HCID 70986 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | p-(4-Phenoxybutoxy) acetophenone | HCID 21844721 | — |
反応手順
A mixture 100 grams (0.438 mole) of 4-phenoxybutyl bromide, 59.5 grams (0.438 mole) of p-hydroxyacetophenone, and 60.4 grams (0.438 mole) of potassium carbonate in approximately 200 milliliters of dry dimethylformamide, is stirred at its reflux temperature for a period of about 4 hours. The reaction mixture is cooled, water added, and the reaction product removed by filtration. The product is washed with a solution of 2 N sodium hydroxide, washed with water, and recrystallized twice from isopropyl alcohol to yield the desired p-(4-phenoxybutoxy) acetophenone having a m.p. of 104°-6° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04038412 |
| 出典データセット | uspto-grants-1977_07 |
| ORD ID | ord-6031a4a6e381409a94a01be0a1234914 |
| 出典メモ | uspto-grants-1977_07 |