O-methylhydroxylammonium chloride → 1-Benzyl-4-methoxyiminopiperidine

HRID 25966

反応式

HRID 25966 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:16][O:17][NH3+:18]>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[N:18][O:17][CH3:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 11639O-methylhydroxylammonium chlorideHCID 192201-Benzyl-4-piperidone

生成物 1

HCID 119596661-Benzyl-4-methoxyiminopiperidine

実験手順

The starting material is prepared as follows: The solution of 94.5 g of 1-benzyl-4-piperidone and 46 g of methoxyammonium chloride in 600 ml of ethanol-pyridine (1:1) is refluxed overnight and evaporated. The residue is dissolved in water, the solution made basic with 12.5% aqueous sodium hydroxide and extracted with diethyl ether. The extract is washed with water and saturated aqueous sodium hydroxide, dried and evaporated, to yield the 1-benzyl-4-methoxyiminopiperidine.

後処理

  1. customThe starting material is prepared
  2. customevaporated
  3. dissolutionThe residue is dissolved in water
  4. extractionextracted with diethyl ether
  5. washThe extract is washed with water and saturated aqueous sodium hydroxide
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-2a1f8645fcbd4743829f06767cb00f3d
出典データセット
uspto-grants-1979_04
特許番号
US04147786

関連ノート

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