2,6-Dimethylquinoline → 4-[2,6-Dimethyl-1quinolinio]butanesulfonate

HRID 259667

反応式

HRID 259667 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N:3]=1.[CH2:13]1[S:18](=[O:20])(=[O:19])[O:17][CH2:16][CH2:15][CH2:14]1>CC(C)=O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N+:3]=1[CH2:16][CH2:15][CH2:14][CH2:13][S:18]([O-:20])(=[O:19])=[O:17]

参加物

4

反応物 2

HCID 134142,6-DimethylquinolineHCID 154111,4-Butane sultone

生成物 1

HCID 867484494-[2,6-Dimethyl-1quinolinio]butanesulfonate収率 94.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

After 72.3 g (0.46 mol) of 2,6-dimethylquinoline and 188 g (1.4 mol) of butane sultone were heated at 145° C. with stirring for 4 hours, the mixture was allowed to cool to room temperature, and 500 ml of acetone was added thereto. While cooling, crystallization was conducted for 30 minutes. The resulting crystal was recovered by filtration, washed with acetone and dried to obtain 127.3 g (yield: 94%) of 4-[2,6-dimethyl-1-quinolinio]butane sulfonate.

後処理

  1. temperatureWhile cooling
  2. customcrystallization
  3. waitwas conducted for 30 minutes
  4. filtrationThe resulting crystal was recovered by filtration
  5. washwashed with acetone
  6. customdried

出典と根拠

ORDレコード
ord-d88cf0498c8c43d8ae8b81cd2e99a3fd
出典データセット
uspto-grants-1996_06
特許番号
US05523203

関連ノート

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