Formamide → 5-chloro-6-methyl-1H-pyrimidin-4-one

HRID 259806

反応式

HRID 259806 の反応式
[NH2:1][C:2]([CH3:9])=[C:3]([Cl:8])[C:4](OC)=[O:5].[CH:10]([NH2:12])=O.C[O-].[Na+]>CO>[Cl:8][C:3]1[C:4]([OH:5])=[N:12][CH:10]=[N:1][C:2]=1[CH3:9]

参加物

5

反応物 3

HCID 713FormamideHCID 10942334Sodium MethoxideHCID 76224675Methyl 3-amino-2-chloro-2-butenoate

生成物 1

HCID 1784332125-chloro-6-methyl-1H-pyrimidin-4-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

25.9 g (0.17 mol) of methyl 3-amino-2-chloro-2-butenoate are reacted with 11.7 g (0.26 mol) of formamide and 51 ml of sodium methylate solution in 20 ml of methanol and worked up in analogy to Example 9 (reaction time 20 h). Yield: 16.6 g (67.5%)

後処理

  1. customworked up in analogy to Example 9 (reaction time 20 h)

出典と根拠

ORDレコード
ord-58ad2a4fdb2f4d9bb1f83c2c5786fa1f
出典データセット
uspto-grants-1996_06
特許番号
US05523404

関連ノート

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