Acetaldehyde → 1-Benzhydrylaminoethane phosphonous acid

HRID 25982ノート

反応式

HRID 25982 の反応式
[CH:1](=O)[CH3:2].[PH2:4]([O-:6])=[O:5].[CH:7]([NH3+:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCOCC1>[CH:7]([NH:20][CH:1]([P:4]([OH:6])[OH:5])[CH3:2])([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 177AcetaldehydeHCID 178527021HCID 178527021、化合物

生成物 1

HCID 213258901-Benzhydrylaminoethane phosphonous acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

0.5 Parts of freshly distilled acetaldehyde was added to a suspension of 2.5 parts of benzhydrylammonium hypophosphite in 10 parts of dioxan at room temperature and the mixture stirred for 15 minutes. The mixture was then heated slowly to 50° when solution occurred and a flocculent precipitate immediately formed. The mixture was allowed to cool to room temperature with vigorous stirring and the orange yellow solid filtered off washed with dioxan and ether and finally with a little cold ethanol to give DL-1-benzhydrylaminoethane phosphonous acid, melting point 220°-221°.

後処理

  1. temperatureThe mixture was then heated slowly to 50° when solution
  2. customa flocculent precipitate immediately formed
  3. stirringwith vigorous stirring
  4. filtrationthe orange yellow solid filtered off
  5. washwashed with dioxan and ether and finally with a little cold ethanol

出典と根拠

ORDレコード
ord-c36872adac9c4d889b5e07045c57da1c
出典データセット
uspto-grants-1979_04
特許番号
US04147780

反応ノート

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