化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Amino-5-fluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 5-Fluoro-2-bromobenzoate | HCID 7015557 | — |
| 触媒 | Cuprous chloride | HCID 62652 | — |
| 生成物 | 2-Amino-5-fluorobenzoic acid | HCID 101412 | 85.4% |
反応手順
Example 9 is repeated precisely, the only difference being that one part of CuCl is added to the initial ammonia solution charge. After the 5-fluoro-2-bromobenzoate solution has been metered in and the batch worked up, 144 parts of 5-fluoroanthranilic acid of m.p. 176.5°-177.5° C. are obtained with a purity of 91.9% (HPLC), corresponding to a yield of 85.4% of theory, based on the 5-fluoro-2-bromobenzoic acid employed.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05523472 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-0d5c3bb66e8b4bc8b7db9d2987871fc0 |
| 出典メモ | uspto-grants-1996_06 |