Sulfuric Acid → 2,3,4,5-Tetrafluorobenzoic acid

HRID 259957

反応式

HRID 259957 の反応式
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[C:6]([F:12])[C:5]=1[F:13].S(=O)(=O)(O)O>O>[F:13][C:5]1[C:6]([F:12])=[C:7]([F:11])[C:8]([F:10])=[CH:9][C:4]=1[C:3]([OH:14])=[O:2]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 600996Methyl 2,3,4,5-tetrafluorobenzoate

生成物 1

HCID 2975492,3,4,5-Tetrafluorobenzoic acid収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a 300 ml three necked flask, 20 g (0.096 mol) of the 2,3,4,5-tetrafluorobenzoic acid-methyl ester prepared in Example 15 and 40 g of 70 wt % sulfuric acid were charged, and the mixture was reacted for 10 hours at 140° C. with stirring. Then, 100 ml of water was added to the reaction solution, and the mixture was left to cool. Then, the mixture was extracted with hot toluene. Then, the solvent was distilled off to obtain 17.1 g of 2,3,4,5-tetrafluorobenzoic acid. The yield was 92%.

後処理

  1. customthe mixture was reacted for 10 hours at 140° C.
  2. waitthe mixture was left
  3. temperatureto cool
  4. extractionThen, the mixture was extracted with hot toluene
  5. distillationThen, the solvent was distilled off

出典と根拠

ORDレコード
ord-34c15b7a62cc4ce48cdb45ab2349b326
出典データセット
uspto-grants-1996_06
特許番号
US05523476

関連ノート

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