5-Chloro-2'-deoxyuridine → HCID 131719429、化合物

反応式

[CH2:1]1[C@H:5]([N:6]2[C:12](=[O:13])[NH:11][C:9](=[O:10])[C:8]([Cl:14])=[CH:7]2)[O:4][C@H:3]([CH2:15][OH:16])[C@H:2]1[OH:17].[C:18]1([C:26]([O-:28])=[O:27])[NH:25][C:23](=[O:24])[NH:22][C:20](=[O:21])[N:19]=1.[K+:29]>>[CH2:1]1[C@H:5]([N:6]2[C:12](=[O:13])[NH:11][C:9](=[O:10])[C:8]([Cl:14])=[CH:7]2)[O:4][C@H:3]([CH2:15][OH:16])[C@H:2]1[OH:17].[C:18]1([C:26]([O-:28])=[O:27])[NH:25][C:23](=[O:24])[NH:22][C:20](=[O:21])[N:19]=1.[K+:29]

参加物

反応物 2

HCID 655105-Chloro-2'-deoxyuridine

HCID 2723920Potassium Oxonate

生成物 1

HCID 131719429HCID 131719429、化合物

実験手順

FT, ClDU and potassium oxonate were suspended at concentrations of 2.0 mg/ml, 0.73 mg/ml and 1.95 mg/ml, respectively, in a 1% solution of hydroxypropylmethylcellulose. The suspension was stirred by a stirrer at room temperature for about 20 minutes and subjected to ultrasonic treatment with ice-cooling for 5 minutes, giving a FT-ClDU-potassium oxonate mixed suspension (test suspension (4)). Test suspensions (5) and (6) were prepared by adding a 1% solution of hydroxypropylmethylcellulose to test suspension (4) to give FT concentrations of 1.0 and 0.5 mg/ml, respectively.

後処理

temperaturecooling for 5 minutes

出典と根拠

ORDレコード: ord-0c705bfa8b6848bca780768d8693c068
出典データセット: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05525603

反応ノート

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