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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 6-Amino-5-(adamantan-1-yl)acetylamino-1,3-dipropyluracil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 1-Adamantaneacetic acid | HCID 123221 | — |
| 反応物 | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| 生成物 | 6-Amino-5-(adamantan-1-yl)acetylamino-1,3-dipropyluracil | HCID 15750284 | 112.8% |
反応手順
At first 2.00 g (8.85 mmol) of 1,3-dipropyl-5,6-diaminouracil and 2.06 g (10.6 mmol) of 1-adamantaneacetic acid were condensed according to the procedure of Example 1 using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide to afford 4.02 g (yield: 100%) of amorphous 6-amino-5-(adamantan-1-yl)acetylamino-1,3-dipropyluracil as a crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05525607 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-acc5d3f03b6c47999ac263f677135dbe |
| 出典メモ | uspto-grants-1996_06 |