化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 5-[[3-Methoxy-2-(phenylmethoxy)phenyl]methylene]-2,4-imidazolidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Beta-Alanine | HCID 239 | — |
| 反応物 | Hydantoin | HCID 10006 | — |
| 反応物 | 2-(Benzyloxy)-3-methoxybenzaldehyde | HCID 1268087 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-[[3-Methoxy-2-(phenylmethoxy)phenyl]methylene]-2,4-imidazolidinedione | HCID 54251091 | 84% |
反応手順
A solution of 96.90 g (0.40 mole) of 2-benzyloxy-3-methoxybenzaldehyde, 48.04 g (0.48 mole) of hydantoin, 8.02 g (0.09 mole) of β-alanine, and 200 mL of glacial acetic acid is stirred at reflux for 6 hours. Water (500 mL) is added and the separated solid is filtered, washed well with water, methanol, and then ether; wt 109.00 g (84% yield); mp 210°-212° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05525614 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-b043e775c0b04d1bad8d7c5c100b6038 |
| 出典メモ | uspto-grants-1996_06 |