4-Methoxy-3-methylbenzyl chloride → (RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

HRID 260079

反応式

HRID 260079 の反応式
[C:1]1([CH:7]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:8]([N:10]2[CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:26][CH3:27])[C:16]=3[OH:25])[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:34][O:35][C:36]1[CH:43]=[CH:42][C:39]([CH2:40]Cl)=[CH:38][C:37]=1[CH3:44]>>[C:28]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]([N:10]2[CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:26][CH3:27])[C:16]=3[O:25][CH2:40][C:39]3[CH:42]=[CH:43][C:36]([O:35][CH3:34])=[C:37]([CH3:44])[CH:38]=3)[CH2:11]2)=[O:9])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

参加物

3

反応物 2

HCID 1437424-Methoxy-3-methylbenzyl chlorideHCID 15296729(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-3-isoquinolinecarboxylic acid, ethyl ester

生成物 1

HCID 15230314(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

実験手順

This compound is prepared from the phenol derivative of Example 31 and 4-methoxy-3-methyl benzyl chloride by a procedure similar to that in Example 32. The product is purified by silica gel chromatography; tlc (1:1 ethyl-acetate/hexane), one spot, Rf 0.7.

後処理

  1. customThe product is purified by silica gel chromatography

出典と根拠

ORDレコード
ord-4bdc901a3e9541aa894e748e1b4136c5
出典データセット
uspto-grants-1996_06
特許番号
US05525614

関連ノート

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