関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 3-Methoxy-2-nitrobenzoic acid | HCID 78632 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Methoxy-2-nitrobenzoyl chloride | HCID 10262731 | 99.7% |
反応手順
Oxalyl chloride (2 mL, 24 mmol) and DMF (0.4 mL) are added to a suspension of 3-methoxy-2-nitro benzoic acid (4 g, 20 mmol) in 200 mL of dichloromethane. The reaction mixture is stirred for 3 hours at 25° C. under nitrogen. The reaction solvents are removed under reduced pressure to yield 3-methoxy-2-nitrobenzoyl chloride (4.3 g, quant.) as a yellow solid. 1H NMR (DMSO): δ7.80 (1H, d, J=8 Hz), 7.65 (1H, t, J=9 Hz), 7.42 (1H, d, J=10 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05525625 |
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| 出典データセット | uspto-grants-1996_06 |
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| ORD ID | ord-68c473f454ac43e7bf0a2f8fde1a2df6 |
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| 出典メモ | uspto-grants-1996_06 |
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