関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Flurbiprofen | HCID 3394 | — |
| 生成物 | Ibuprofen, (+-)- | HCID 3672 | — |
反応手順
Three grams of flurbiprofen and 30 g of poloxamer 237 were heated at 110° C. for 10 minutes to obtain a liquified mixture and cooled to 60° C. Into this mixture, 5 g of polyethylene glycol 300, 10 g of ethanol and 52 g of pH 4 buffer solution were added at 60° C. to obtain an ibuprofen gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05527832 |
|---|
| 出典データセット | uspto-grants-1996_06 |
|---|
| ORD ID | ord-b0ad4fad120e4b30b6d002e81134c3db |
|---|
| 出典メモ | uspto-grants-1996_06 |
|---|
