化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Bromide → Diethyl 2-hydroxybenzene-1,4-dicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Bromide | HCID 6332 | — |
| 反応物 | Bromoterephthalic acid | HCID 68513 | — |
| 反応物 | 2-Hydroxyterephthalic acid | HCID 97257 | — |
| 反応物 | 1,8-Diazabicyclo[5.4.0]undec-2-ene | HCID 9812821 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Diethyl 2-hydroxybenzene-1,4-dicarboxylate | HCID 22401614 | — |
反応手順
6.62 g of 1,8-diazabicyclo[5.4.0]undecene and 100 mL benzene were added to 3.76 g hydroxyterephthalic acid (synthesized from bromoterephthalic acid by a known method) and the mixture was heated. 6.76 g of bromoethane dissolved in 38 mL benzene was added dropwise in and the reaction mixture was heated under reflux for 19 hours. The salt product was filtered off, and purification by column chromatography then yielded 4.66 g diethyl hydroxyterephthalate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05527862 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-b3305a26870c4436b3ea5f4482976b00 |
| 出典メモ | uspto-grants-1996_06 |