Thiophenol → HCID 19426995、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[O:10])[CH:5]=[C:6](F)[CH:7]=1.[C:16]1([SH:22])C=CC=CC=1.C[S-].[Na+].[NH4+].[Cl-]>CN(C=O)C>[CH3:16][S:22][C:6]1[CH:5]=[C:4]([C:9]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[O:10])[CH:3]=[C:2]([F:1])[CH:7]=1参加物
6
実験手順
To a solution of (3,5-difluorophenyl)(thiazol-2-yl)methanone from Thiophenol 2, Step 2, (1.09 g, 4.84 mmol) in DMF (4.8 mL) was added sodium thiomethoxide (0.34 g, 4.84 mmol). The mixture was stirred for 4 h at r.t., then added to sat. aqueous NH4Cl (100 mL) and extracted with EtOAc. The combined organic layers were washed with brine and dried over anhydrous MgSO4. Evaporation of the solvent and chromatography using hexane: EtOAc (90:10) gave 0.80 g of the title product.
後処理
- extractionextracted with EtOAc
- washThe combined organic layers were washed with brine
- dry with materialdried over anhydrous MgSO4
- customEvaporation of the solvent and chromatography
出典と根拠
- ORDレコード
- ord-087e4d73e6e5457ebc24291496950a70
- 出典データセット
- uspto-grants-1996_06
- 特許番号
- US05527827
反応ノート
読み込み中…