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M-Cresol → Cresatin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | M-Cresol | HCID 342 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Cresatin | HCID 67406 | 97.2% |
反応手順
To a solution of m-cresol (Aldrich) (80 g, 0.74 mol) in dry CH2Cl2 (300 mL) was added pyridine (71 mL, 0.89 mol) and at 0° C. was added dropwise acetyl chloride (58 mL, 0.81 mol). The reaction mixture was stirred for 1 h and then diluted with more CH2Cl2. The organic phase was washed successively with HCl 1N (3×), brine, dried over MgSO4 and evaporated. The residue was distilled under vacuum to give 108 g (97%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05527827 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-b86af76b6d02406091ceb8a37c468bc4 |
| 出典メモ | uspto-grants-1996_06 |