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Ethyl Acetate → 7-Bromo-4-(thiazol-4-yl)coumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Methanethioamide | HCID 3005587 | — |
| 反応物 | 7-bromo-4-(bromoacetyl)-2H-chromen-2-one | HCID 23370239 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-Bromo-4-(thiazol-4-yl)coumarin | HCID 19426943 | — |
反応手順
Freshly prepared thioformamide (Helv. Chim. Acta, 31, 2065, 1948) (160 mg) was added to a solution of (α-bromoketone from Step 2 (200 mg) in THF (5 mL) and the reaction mixture was stirred at r.t. for 2 h. Ethyl acetate was then added and the organic phase was washed with saturated aqueous NH4Cl, H2O and brine, dried (MgSO4) and evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (65:35) afforded the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05527827 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-f263892467124d7491ef5fa10b99c9fb |
| 出典メモ | uspto-grants-1996_06 |