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Hydrochloric Acid → N-[(1,2-Dihydro-2-methyl-1-oxo-4-phenylisoquinolin-3-yl)methyl]-N'-[3-(dimethylaminomethyl)phenyl]urea hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 3-amino-N,N-dimethylbenzylamine | HCID 99294 | — |
| 反応物 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 反応物 | 1,2-Dihydro-2-methyl-1-oxo-4-phenyl-3-isoquinoline acetic acid | HCID 10402129 | — |
| 生成物 | N-[(1,2-Dihydro-2-methyl-1-oxo-4-phenylisoquinolin-3-yl)methyl]-N'-[3-(dimethylaminomethyl)phenyl]urea hydrochloride | HCID 22401314 | — |
反応手順
Using 1,2-dihydro-2-methyl-1-oxo-4-phenyl-3-isoquinoline acetic acid, diphenylphosphoryl azide and 3-(dimethylaminomethyl)aniline, the reaction was carried out by substantially the same procedure as in Method B of Example 1, followed by treatment of the product with hydrogen chloride in ethyl acetate to give the title compound as a white powdery product. NMR (200 MHz,DMSO-d6) ppm: 2.67(3H,s), 2.69(3H,s), 3.64(3H,s), 4.17(4H,m), 6.9-7.2(4H,m), 7.3-7.7(9H,m), 8.32(1H,m), 9.09(1H,bs)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05527811 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-20135b24567f494ca98b81410a796d51 |
| 出典メモ | uspto-grants-1996_06 |