Ammonium Chloride → 3-Benzenesulfonyl-5-chloroindole-2-carboxamide

HRID 260479ノート

反応式

HRID 260479 の反応式
[C:1]1([S:7]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=3)[NH:12][C:11]=2[C:20]([O:22]CC)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[NH4+:26]>[OH-].[NH4+]>[C:1]1([S:7]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=3)[NH:12][C:11]=2[C:20]([NH2:26])=[O:22])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 25517Ammonium ChlorideHCID 22401503Ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate

生成物 1

HCID 4548443-Benzenesulfonyl-5-chloroindole-2-carboxamide

試薬・触媒・溶媒 1

HCID 14923Ammonium Hydroxide溶媒

反応条件

温度
100 °C

実験手順

A suspension of ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate (596 mg, 1.64 mmol) in aqueous conc. ammonium hydroxide (10 mL) containing ammonium chloride (28 mg) was heated at 100° C. for 3 hours in a sealed screw-top tube. The sealed tube was cooled in an ice bath as product crystallized out. The product was collected by filtration, rinsed with ice water, and dried to give the product, mp 253°-254° C.

後処理

  1. temperatureThe sealed tube was cooled in an ice bath as product
  2. customcrystallized out
  3. filtrationThe product was collected by filtration
  4. washrinsed with ice water
  5. customdried
  6. customto give the product, mp 253°-254° C.

出典と根拠

ORDレコード
ord-1938ad879d994b299f62cfe8700855bb
出典データセット
uspto-grants-1996_06
特許番号
US05527819

反応ノート

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