Cyanamide → 3-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine

HRID 260496ノート

反応式

HRID 260496 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11](=[NH:15])OCC)=[C:5]2[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17].[N:25]#[C:26][NH2:27]>CO>[C:26]([NH:27][C:11]([C:6]1[NH:7][C:8]2[C:4]([C:5]=1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17])=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)=[NH:15])#[N:25]

参加物

4

反応物 2

HCID 9864CyanamideHCID 135761968Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate

生成物 1

HCID 1785123053-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate is reacted with an equimolar amount of cyanamide in absolute methanol (according to the procedure of K. R. Huffman and F. C. Schaefer (J. Org. Chem., 28, 1812 (1963)). After 30-60 minutes the solvent is removed and the residue purified by silica gel chromatography to afford the title compound.

後処理

  1. customAfter 30-60 minutes the solvent is removed
  2. customthe residue purified by silica gel chromatography

出典と根拠

ORDレコード
ord-137b4c1d36df4ac9a6d032cd522cafed
出典データセット
uspto-grants-1996_06
特許番号
US05527819

反応ノート

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