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2-Amino-5-methylthiazole → 2-(2,3-Dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-methylthiazole | HCID 351770 | — |
| 反応物 | 2-Bromo-1-(thiophen-2-yl)ethan-1-one | HCID 2776372 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(2,3-Dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide | HCID 22401741 | — |
反応手順
A mixture of 51 parts of 2-bromo-1-(2-thienyl)ethanone, 28.5 parts of 5-methyl-2-thiazolamine and 240 parts of acetonitrile was stirred for 1 hour while heating on a water-bath. After cooling, the precipitate was filtered off, washed with ethanol and dried in vacuo, yielding 54 parts of 2-(2,3-dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide; mp. 207.5°-208° C (interm. 56).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05527915 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-f21da8212cc340c0b8a25b691cce9bce |
| 出典メモ | uspto-grants-1996_06 |