1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole → methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride

HRID 260748ノート

反応式

HRID 260748 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH:14](C(OCC)=O)[C:15]([O:17][CH2:18]C)=[O:16])=[CH:12][N:11]=[C:10]1[S:25][CH2:26][CH2:27][CH3:28].ClC1C=CC=CC=1CN1C(CC(O)=O)=CN=C1SCCC>CO.Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:12][N:11]=[C:10]1[S:25][CH2:26][CH2:27][CH3:28]

参加物

4

反応物 2

HCID 193515541-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazoleHCID 54435009Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate

生成物 1

HCID 22400438methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride

試薬・触媒・溶媒 1

HCID 21893726Hydrochloride methanol溶媒

実験手順

Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate was converted to 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetic acid by the method described in Example 15. The methyl ester was prepared in methanol/hydrochloric acid to give methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride; mp 158°-159° C.

出典と根拠

ORDレコード
ord-ae77781c34434ed28415577bc0001136
出典データセット
uspto-grants-1996_06
特許番号
US05530017

反応ノート

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