化工社化工社 化学情報印刷レポート · 研究参考用
(R)-3,3-Dimethyl-2-aminobutane → (+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-3,3-Dimethyl-2-aminobutane | HCID 5324845 | — |
| 反応物 | 4-[(2-Ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino]benzonitrile | HCID 10824058 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-benzonitrile | HCID 10613948 | 75.5% |
反応手順
4-(3,4-Dioxo-2-ethoxy-cyclobut-1-enylamino)-benzonitrile (1 g, 4.1 mmol) and a solution of (R)-1,2,2-trimethylpropylamine (8.2 mmol) in ethanol (50 mL) were stirred at room temperature for 24 hours. The resulting yellow slurry was filtered and rinsed with ethyl acetate to yield 0.92 g (75%) of (+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-benzonitrile as a yellow solid: spectral data was identical to the product of Example 1, paragraph 2, except with [α]D25 =+12° (DMSO, c 0.009).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05530025 |
| 出典データセット | uspto-grants-1996_06 |
| ORD ID | ord-bdb368b71c6144d4a51e82edda09a65e |
| 出典メモ | uspto-grants-1996_06 |