Isobutylbenzene → 4'-Isobutylpentanophenone

HRID 260823ノート

反応式

HRID 260823 の反応式
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[Cl-].[Al+3].[Cl-].[Cl-].[CH2:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH:13]([CH3:15])[CH3:14]>ClCCl>[CH2:12]([C:16]1[CH:21]=[CH:20][C:19]([C:1](=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5])=[CH:18][CH:17]=1)[CH:13]([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 10870IsobutylbenzeneHCID 61186Valeryl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 109984904'-Isobutylpentanophenone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

A mixture of valeryl chloride and aluminium chloride in dichloromethane was stirred at 0° C. for 30 minutes, and then isobutylbenzene was added. After stirring at 0° C. for 1 hour, the mixture was poured into ice water and extracted with dichloromethane. The organic layer was washed with an aqueous solution of sodium bicarbonate and brine, dried over magnesium sulfate and concentrated to give the object compound.

後処理

  1. stirringAfter stirring at 0° C. for 1 hour
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with an aqueous solution of sodium bicarbonate and brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. customto give the object compound

出典と根拠

ORDレコード
ord-5ece0742f6e64f89ba2410412f18cc4f
出典データセット
uspto-grants-1996_06
特許番号
US05530019

反応ノート

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