Methylamine → HCID 178484998、化合物

HRID 261098ノート

反応式

HRID 261098 の反応式
[CH3:1][NH2:2].[C:3]([NH:5][C:6](=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])SC)#[N:4]>C(O)C>[C:3]([NH:5][C:6]([NH:2][CH3:1])=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])#[N:4]

参加物

4

反応物 2

HCID 6329MethylamineHCID 1036301-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea

生成物 1

HCID 178484998HCID 178484998、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 75 ml of 33% methylamine in ethanol was added to a solution of 10.1 g of N-cyano-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-S-methylisothiourea in 30 ml of ethanol. The reaction mixture was set aside at ambient temperature for 2.5 hours. Following concentration under reduced pressure, the residue was recrystallized twice from isopropanol-petroleum ether to give N-cyano-N'-methyl-N"-[2-(5-methyl-4-imidazolylmethylthio)ethyl]guanidine, m.p. 141°-143°.

後処理

  1. concentrationconcentration under reduced pressure
  2. customthe residue was recrystallized twice from isopropanol-petroleum ether

出典と根拠

ORDレコード
ord-30e1b384fbd54af19cb8181ce1cfa339
出典データセット
uspto-grants-1979_08
特許番号
US04163858

反応ノート

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