Phosphorus oxychloride → Imidazo(1,5-a)pyridine
反応式
[CH:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)=O.P(Cl)(Cl)(Cl)=O>>[CH:4]1[N:3]=[CH:1][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12参加物
3
実験手順
To 13.6 g. of 2-formamidomethylpyridine in a round-bottom flask is added 25 ml. of phosphorous oxychloride. Following the exothermic reaction, the reaction mixture is cooled to room temperature, and quenched on crushed ice. The aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution to provide a pH of 9-10, and the liberated product extracted into chloroform (3×300 ml.). The extracts are combined, dried over sodium sulfate and concentrated to a light brown oil, 14.0 g.
後処理
- customthe exothermic reaction
- customquenched
- customon crushed ice
- additionThe aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution
- customto provide a pH of 9-10
- extractionthe liberated product extracted into chloroform (3×300 ml.)
- dry with materialdried over sodium sulfate
- concentrationconcentrated to a light brown oil, 14.0 g
出典と根拠
- ORDレコード
- ord-64fcf6fa6d1244098a9644779914d8e1
- 出典データセット
- uspto-grants-1979_08
- 特許番号
- US04163745
反応ノート
読み込み中…