Phosphorus oxychloride → Imidazo(1,5-a)pyridine

HRID 261124ノート

反応式

HRID 261124 の反応式
[CH:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)=O.P(Cl)(Cl)(Cl)=O>>[CH:4]1[N:3]=[CH:1][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 12228441N-Pyridin-2-ylmethyl-formamide

生成物 1

HCID 274090Imidazo(1,5-a)pyridine

実験手順

To 13.6 g. of 2-formamidomethylpyridine in a round-bottom flask is added 25 ml. of phosphorous oxychloride. Following the exothermic reaction, the reaction mixture is cooled to room temperature, and quenched on crushed ice. The aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution to provide a pH of 9-10, and the liberated product extracted into chloroform (3×300 ml.). The extracts are combined, dried over sodium sulfate and concentrated to give imidazo[1,5-a]pyridine as a light brown oil, 14.0 g.

後処理

  1. customthe exothermic reaction
  2. customquenched
  3. customon crushed ice
  4. additionThe aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution
  5. customto provide a pH of 9-10
  6. extractionthe liberated product extracted into chloroform (3×300 ml.)
  7. dry with materialdried over sodium sulfate
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-5019be3f2a5b482b9f5c4aab1b65831e
出典データセット
uspto-grants-1979_08
特許番号
US04163745

反応ノート

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