3-Methoxyacetophenone → Ethyl 3-(3-Benzyloxyphenyl)crotonate

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:9](/[CH3:16])=[CH:10]\[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1.CC([C:20]1[CH:25]=[CH:24][CH:23]=[C:22](OC)[CH:21]=1)=O.C(C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(OCC)=O>>[CH2:1]([O:2][C:3]1[CH:4]=[C:5](/[C:9](/[CH3:16])=[CH:10]\[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

反応物 3

HCID 114603-Methoxyacetophenone

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester

HCID 70595204(Z)-ethyl 3-(3-methoxyphenyl)but-2-enoate

生成物 1

HCID 70527588Ethyl 3-(3-Benzyloxyphenyl)crotonate

実験手順

In like manner, ethyl 3-(3-methoxyphenyl)crotonate is prepared from 3-methoxyacetophenone (43.1 g.) and carbethoxymethylene triphenylphosphorane (200 g.).

出典と根拠

ORDレコード: ord-8b9e6c5aa7f44d1085c999ff5d3ba9b4
出典データセット: uspto-grants-1979_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04165323

反応ノート

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