N-Phenylphthalimide → 2,3-Dihydro-2-phenyl-1H-isoindol-1-one

HRID 261522

反応式

HRID 261522 の反応式
[C:1]1([N:7]2[C:11](=O)[C:10]3=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]3[C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Zn].C(O)(=O)C>[CH2:11]1[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:17])[C:9]2[C:10]1=[CH:13][CH:14]=[CH:15][CH:16]=2

参加物

4

反応物 1

HCID 68215N-Phenylphthalimide

生成物 1

HCID 970352,3-Dihydro-2-phenyl-1H-isoindol-1-one収率 78%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

A mixture of N-phenylphthalimide (100 g), zinc powder (147 g) and acetic acid (700 ml) is heated under reflux for 5.5 hours with stirring. After cooling, the mixture is filtered and the insoluble solid is washed with hot acetic acid (100 ml). The combined filtrate and washings are concentrated to give crystal (72 g, 78%). Recrystallization from benzene gives colorless scales. Melting point: 166° to 167° C.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 5.5 hours
  3. temperatureAfter cooling
  4. filtrationthe mixture is filtered
  5. washthe insoluble solid is washed with hot acetic acid (100 ml)
  6. concentrationThe combined filtrate and washings are concentrated

出典と根拠

ORDレコード
ord-45d7bbf4da3a4ad8808211dd6c270b8c
出典データセット
uspto-grants-1979_08
特許番号
US04166125

関連ノート

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