Potassium Hydroxide → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 261524

反応式

HRID 261524 の反応式
[OH-].[K+].C[O:4][C:5](=[O:21])[C:6](O)([CH3:19])[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[CH2:12][CH:11]([CH:16]([CH3:18])[CH3:17])[CH2:10]2>O.CO>[CH:16]([CH:11]1[CH2:10][C:9]2[C:13](=[CH:14][CH:15]=[C:7]([CH:6]([CH3:19])[C:5]([OH:21])=[O:4])[CH:8]=2)[CH2:12]1)([CH3:18])[CH3:17]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 53680234alpha-Hydroxy-2-isopropyl-alpha-methyl-5-indanacetic acid methyl ester

生成物 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 26.6 g of potassium hydroxide in 50 cc of water is added to a solution of 41.5 g of crude α-hydroxy-2-isopropyl-α-methyl-5-indanacetic acid methyl ester in 500 cc of methanol, and the mixture is boiled at reflux for 11/2 hours. The solution is concentrated, diluted with water and extracted with ether in order to remove the neutral components. The aqueous phase is then acidified with hydrochloric acid, extracted with ether, the ether extract is washed with water, dried over sodium sulphate and concentrated by evaporation. The resulting α-hydroxy-2-isopropyl-α-methyl-5-indanacetic acid is recrystallized from ether/hexane and has a M.P. of 126°-130°.

後処理

  1. temperatureat reflux for 11/2 hours
  2. concentrationThe solution is concentrated
  3. additiondiluted with water
  4. extractionextracted with ether in order
  5. customto remove the neutral components
  6. extractionextracted with ether
  7. extractionthe ether extract
  8. washis washed with water
  9. dry with materialdried over sodium sulphate
  10. concentrationconcentrated by evaporation
  11. customThe resulting α-hydroxy-2-isopropyl-α-methyl-5-indanacetic acid is recrystallized from ether/hexane

出典と根拠

ORDレコード
ord-bbaf21dc083a46b98b575bef384bf315
出典データセット
uspto-grants-1979_08
特許番号
US04166131

関連ノート

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