Selenium Dioxide → 2-(3-(Benzyloxy)phenyl)-2-oxoacetaldehyde

HRID 261603

反応式

HRID 261603 の反応式
[Se](=O)=O.[O:4]1CCOCC1.[CH3:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:14]=1)=[O:12]>O>[CH2:20]([O:19][C:15]1[CH:14]=[C:13]([C:11]([CH:10]=[O:4])=[O:12])[CH:18]=[CH:17][CH:16]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 24007Selenium DioxideHCID 312751,4-DioxaneHCID 986891-(3-(Phenylmethoxy)phenyl)ethan-1-one

生成物 1

HCID 134580312-(3-(Benzyloxy)phenyl)-2-oxoacetaldehyde

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 9.4 g. of selenium dioxide in a solvent mixture of 50 ml. of dioxane and 1.7 ml. of water, was added 16.5 g. of 3-benzyloxyacetophenone. The mixture was refluxed for 4 hrs. with stirring. The resulting precipitates were removed by filtration and the solvents were distilled off from the filtrate under reduced pressure. The residue was dissolved in benzene and washed with water several times. After drying the benzene layer, benzene was removed by distillation to obtain the glyoxal as yellow liquid in a quantitative yield.

後処理

  1. temperatureThe mixture was refluxed for 4 hrs
  2. customThe resulting precipitates
  3. customwere removed by filtration
  4. distillationthe solvents were distilled off from the filtrate under reduced pressure
  5. dissolutionThe residue was dissolved in benzene
  6. washwashed with water several times
  7. dry with materialAfter drying the benzene layer, benzene
  8. customwas removed by distillation

出典と根拠

ORDレコード
ord-5c05fd5f8379424e8e6798a5a0ae7acd
出典データセット
uspto-grants-1979_08
特許番号
US04166180

関連ノート

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