Ethanol → Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate
反応式
ON=[C:3]([C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].C([OH:17])C.S(=O)(O)[O-].[Na+]>O>[NH2:14][C:11]1[S:12][CH:13]=[C:9]([C:3](=[O:17])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:10]=1参加物
5
実験手順
A mixture of ethyl 2-hydroxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate (a mixture of syn and anti isomers) (0.37 g), ethanol (5 ml), water (5 ml) and sodium bisulfite (0.72 g) was stirred for 12 hours at 65° to 70° C. The reaction mixture was concentrated and water (10 ml) was added to the residue. The resulting mixture was subjected to salting-out and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated to give yellow crystals of ethyl 2-(2-amino-1,3-thiazol-4-yl)glyoxylate (0.18 g), mp 115° to 120° C.
後処理
- concentrationThe reaction mixture was concentrated
- additionwater (10 ml) was added to the residue
- extractionextracted with ethyl acetate
- dry with materialThe extract was dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5e5c1c2b9bea493984df1ffe65c8cfa6
- 出典データセット
- uspto-grants-1979_08
- 特許番号
- US04166115
反応ノート
読み込み中…