Ethanol → Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

HRID 261679

反応式

HRID 261679 の反応式
ON=[C:3]([C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].C([OH:17])C.S(=O)(O)[O-].[Na+]>O>[NH2:14][C:11]1[S:12][CH:13]=[C:9]([C:3](=[O:17])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:10]=1

参加物

5

反応物 3

HCID 702EthanolHCID 6738988Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetateHCID 23665763Sodium Bisulfite

生成物 1

HCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of ethyl 2-hydroxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate (a mixture of syn and anti isomers) (0.37 g), ethanol (5 ml), water (5 ml) and sodium bisulfite (0.72 g) was stirred for 12 hours at 65° to 70° C. The reaction mixture was concentrated and water (10 ml) was added to the residue. The resulting mixture was subjected to salting-out and extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated to give yellow crystals of ethyl 2-(2-amino-1,3-thiazol-4-yl)glyoxylate (0.18 g), mp 115° to 120° C.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater (10 ml) was added to the residue
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract was dried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5e5c1c2b9bea493984df1ffe65c8cfa6
出典データセット
uspto-grants-1979_08
特許番号
US04166115

関連ノート

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