関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Propargyl alcohol | HCID 7859 | — |
| 反応物 | Diethylamine | HCID 8021 | — |
| 触媒 | Copper Sulfate | HCID 24462 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Diethylamino)-2-butyn-1-ol | HCID 82735 | 86% |
反応手順
204 parts by weight of aqueous 55% strength propargyl alcohol, 250 parts by weight of 30% strength aqueous formaldehyde, 161 parts by weight of diethylamine, 1.4 parts by weight of copper sulfate, 2 parts by weight of potassium iodide, 50 parts by weight of water and 115 parts by weight of concentrated sulfuric acid are mixed and brought to pH 5. The mixture is heated for 5 hours at 92° C. and worked up as described. 242 parts by weight of 1-diethylaminobut-2-yn-4-ol are obtained, corresponding to a yield of 86%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04148824 |
|---|
| 出典データセット | uspto-grants-1979_04 |
|---|
| ORD ID | ord-947d44843c3f4b7fbab1d2263be8b0ed |
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| 出典メモ | uspto-grants-1979_04 |
|---|
