Dimethylformamide → 3,5-diphenyl-4(1H)-pyridone

HRID 261774

反応式

HRID 261774 の反応式
[C:1]1([CH2:7][C:8](=[O:16])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17]([NH:19][CH:20](NC=O)NC=O)=O.CN(C)C=O>O>[C:1]1([C:7]2[C:8](=[O:16])[C:9]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:20][NH:19][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 75931,3-Diphenyl-2-propanoneHCID 78505N,N',N''-Methylidynetrisformamide

生成物 1

HCID 124666803,5-diphenyl-4(1H)-pyridone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 1.4 g. portion of 1,3-diphenyl-2-propanone was mixed with 1.0 g. of tris(formylamino)methane in 20 ml. of dimethylformamide. The reaction mixture was stirred at reflux temperature for 3 hours. The mixture was then cooled to approximately room temperature, and poured into water. The precipitated solids were separated by filtration, and the solids were suspended in chloroform. The chloroform was then filtered, and the solids remaining were washed first with water, and then with chloroform. The yield was about 100 mg. of 3,5-diphenyl-4(1H)-pyridone, m.p. greater than 335° C.

後処理

  1. temperatureat reflux temperature for 3 hours
  2. temperatureThe mixture was then cooled to approximately room temperature
  3. customThe precipitated solids were separated by filtration
  4. filtrationThe chloroform was then filtered
  5. washthe solids remaining were washed first with water

出典と根拠

ORDレコード
ord-2a7aa077b06e428d88b89725156bd94f
出典データセット
uspto-grants-1979_05
特許番号
US04152136

関連ノート

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