1,3-Dihydro-1-(1-methylvinyl)-2H-benzimidazol-2-one → 4-Benzyl-2-(1-isopropenyl-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine

HRID 261781

反応式

HRID 261781 の反応式
[C:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=[O:13])([CH3:3])=[CH2:2].Cl[CH2:15][CH:16]1[O:21][CH2:20][CH2:19][N:18]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:17]1>>[CH2:22]([N:18]1[CH2:19][CH2:20][O:21][CH:16]([CH2:15][N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]([C:1]([CH3:3])=[CH2:2])[C:5]2=[O:13])[CH2:17]1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

参加物

3

反応物 2

HCID 1002781,3-Dihydro-1-(1-methylvinyl)-2H-benzimidazol-2-oneHCID 28015624-Benzyl-2-(chloromethyl)morpholine

生成物 1

HCID 706017934-Benzyl-2-(1-isopropenyl-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine収率 72.9%

実験手順

The condensation of 0.1 mol of 1-isopropenyl-2,3-dihydro-benzimidazol-2-one and 0.1 mol of 2-chloromethyl-4-benzyl-morpholine in accordance with the procedure (a) of Example 1 gives, after evaporation of the solvent under reduced pressure, 30 g of an oil which solidifies slowly. Recrystallization from a 250/25 mixture of isopropyl ether and isopropanol gives 26.5 g of 4-benzyl-2-(1-isopropenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine, m.p. 117° C.

後処理

  1. customgives
  2. customafter evaporation of the solvent under reduced pressure, 30 g of an oil which
  3. customRecrystallization
  4. additionfrom a 250/25 mixture of isopropyl ether and isopropanol

出典と根拠

ORDレコード
ord-904b9faac97943d9b31c7a5f637c8afd
出典データセット
uspto-grants-1979_05
特許番号
US04152434

関連ノート

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