UP 614-04 → 2-(1-Isopropyl-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine

HRID 261782ノート

反応式

HRID 261782 の反応式
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]([C:24]([CH3:26])=[CH2:25])[C:16]2=[O:27])[CH2:9]1)C1C=CC=CC=1.Cl.CN1C2C=CC=CC=2N(CC2OCCNC2)C1=O>>[CH:24]([N:17]1[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N:15]([CH2:14][CH:10]2[O:11][CH2:12][CH2:13][NH:8][CH2:9]2)[C:16]1=[O:27])([CH3:26])[CH3:25]

参加物

3

反応物 2

HCID 134375UP 614-04HCID 706017934-Benzyl-2-(1-isopropenyl-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine

生成物 1

HCID 706017602-(1-Isopropyl-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine収率 71.1%

実験手順

26 g of 4-benzyl-2-(1-isopropenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, a limpid oil is obtained, which crystallizes slowly. Recrystallization from isopropyl ether gives 14 g of 2-(1-isopropyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine, m.p. 95° C.

後処理

  1. customAfter evaporation of the solvent under reduced pressure
  2. customa limpid oil is obtained
  3. customwhich crystallizes slowly
  4. customRecrystallization from isopropyl ether

出典と根拠

ORDレコード
ord-534debead15c4af88646569b23e84c7d
出典データセット
uspto-grants-1979_05
特許番号
US04152434

反応ノート

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